http://www.health-andme.com/capsules-exp/
People accept arthritic disease as a "natural part of aging process, but sometimes the pain of osteoarthritis, rheumatoid arthritis, and more than 100 forms of arthritis so intolerable, prompting people to find effective treatment.
Prescription drugs such as Vioxx, Bextra and Celebrex (arthritic painkillers) – and many other COX-2 inhibitors widely used for treating arthritis – have been studied after studying their effects in cardiovascular side. VIOXX alone has been linked to about 140,000 cases of coronary disease in the United States since 1999.
Increasingly seeking alternatives to arthritis pain and people increasingly buying the combination of glucosamine sulfate Chondroitin and MSN, as studies have shown that glucosamine and chondroitin to help repair and maintenance of cartilage.
The two inflammation and oxidative stress function are primary degenerative mechanisms in the development and progression of osteoarthritis. Although researchers believe that glucosamine inhibits inflammation and stimulates cell growth cartilage and chondroitin provides cartilage with strength and resistance, amino acids specific is also necessary for a global impact.
Amino acids are the building blocks that make up proteins. Vitamins and minerals do function not of their specific functions effectively if the necessary amino acids are not present.
Three amino acids are essential the antioxidant, anti-inflammatory functions: cysteine, glutathione, and taurine.
Cysteine affects the synthesis of the antioxidant glutathione (GSH), which plays an important role in the inflammatory response by influencing the production of phagocytes.
Taurine acts as a scavenger for specific ion hypochlorite, a free radical. Appropriate levels of taurine naturally limits the degree of inflammation. When taurine is low, the inflammatory response is improved, This often leads to oxidative stress.
Other amino acid imbalances may also impact the etiology of osteoarthritis – especially the methionine metabolism. Normally, B12 and folic acid are necessary for the body to metabolize homocysteine methionine, an essential amino acid the body needs to produce S-adenosylmethionine. Many clinical trials have shown that S-adenosylmethionine may greatly reduce the damage and degenerative symptoms of osteoarthritis in some patients, including depression related.
Imbalances amino acids in the May also signal to the main deficiencies in vitamins and minerals in part of the musculoskeletal system. Experimental studies show that the structure of cartilage with impaired can be induced by a deficiency of vitamin B6. Vitamin B6 activates the transformation of the amino acid homocysteine to cystathionine and then cysteine and its urinary metabolites.
Not all amino acids are identical. Amino acids can be from a variety of sources, including vegetables, meat, fish and cartilage.
For treatment of arthritis, the source most compatible with the amino acid is animal cartilage, including swine, cartilage and keel borvine young chicken. Joint TLC is one of those products (www.holistictlc.com) combining chondroitin, glucosamine and essential amino acids that promotes joint health, but this combination is still rare because most still use MSN instead of cartilage-derived amino acids, such as MSN, for marketing, is less expensive.
References:
1 Bradley JD, Flusser D, Katz BP, Schumacher HR Jr, Brandt KD, Chambers MA, Zonay LJ. A randomized, double-blind, placebo-controlled trial of intravenous loading with S-adenosyltmethionine (SAM), followed by SAM oral therapy in patients with osteoarthritis of the knee. J Rheumatol 1994; 21 (5) :905-11.
2 HA Barcelo, JC Wiemeyer, Sagasta CL, Macias M, Barreira JC. Experimental osteoarthritis and its course when treated with S-adenosyl-L-methionine. [Spanish) Rev Clin Esp 1990 187 (20:74-78.
3 B. Konig In the long term (two years) clinical trial with S-adenosylmethionine for the treatment of osteoarthritis. Am J Med 1987; 83 (5A) :89-94.
4 Baldessarini RJ. Neuropharmacology of S-adenosyl-L-methionine. Am J Med 1987; 83 (5A) :95-103.
5 di Padova C. S-adenosylmethionine in the treatment of osteoarthritis. Review of clinical studies. Am J Med 1987; 83 (5A) :60-5.
6 Flynn MA, Irvin W, Krause G. The effect of folate and cobalamin on osteoarthritic hands. J Am Coll Nutr 1994; 13 (4) :351-6.
7 McCarty MF. The neglect of glucosamine for treating osteoarthritis – a personal perspective. Med Hypotheses 1994; 42 (5) :323-7.
8 Earth PG, Ziv I, Cole DE, Mahuren JD, Donovan SM, Yamauchi M, Howell DS. A cartilage matrix deficiency experimentally induced deficiency vitamin B6. Proc Soc Exp Biol Med 1998; 217 (1) :97-103.
James Well consults to nutrition industry, specializing in Diet, Energy, Libido and Diabetes care and other related holistic products. He directs a research lab facility among other projects.
Pokemon Pearl Playthrough – Part 29 – A Day at The Daycare!
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